AbstractBackground Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) remains the leading cause of treatment failure in advanced non-small cell lung cancer (NSCLC) patients harboring sensitizing EGFR mutations. This study aims to investigate the underlying resistance mechanisms in...
AbstractBackground Calcium/calmodulin-dependent serine protein kinase (CASK), a member of the membrane-associated guanylate kinase (MAGUK) family, functions as a multifunctional scaffold protein by engaging diverse binding partners. Although CASK has been implicated in tumorigenesis, its molecular role in the pathogenesis of...
Abstract Genetic fusion involving the ROS1 gene lead to the constitutive activation of its encoded tyrosine kinase, thereby acting as an oncogenic driver that promotes tumor cell proliferation. Numerous missense mutations in ROS1 are currently classified as variants of unknown...
Article summary AI generated Glioma's molecular heterogeneity complicates the development of personalized treatment strategies, highlighting the need for a deeper understanding of its subtypes. This study successfully integrated bulk and single-cell transcriptomic analyses to identify distinct transcriptome-defined groups and elucidate...
AbstractMolecular fluorescence imaging is effective for tumor diagnosis but limited by low-depth profiling, which can be addressed by photoacoustic (PA) imaging. However, PA imaging has low sensitivity due to microenvironment-induced effects on exogenous contrast agents. Accordingly, the temporal and biophysical...
AbstractObjective Previous studies have found that the relationship between changes in BMI and renal function outcomes remains unclear, with both increases and decreases in BMI being associated with a decline in eGFR, especially in the elderly hip fracture population. Therefore,...
Contrasting temporal dynamics of fluorescence and photoacoustic signals from Cetuximab-IRDye800 conjugate in EGFR-overexpressing tumors Molecular fluorescence imaging is effective for tumor diagnosis but limited by low-depth profiling, which can be addressed by photoacoustic (PA) imaging. However, PA imaging has low...
AbstractBackground Although tyrosine kinase inhibitors (TKIs) significantly improve survival outcomes in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), tumor clonal evolution under drug pressure inevitably leads to acquired resistance. DNA damage response (DDR) mutations lead...
Open AccessArticle Construction of EGFR-Targeted Triptolide Liposomes Using Uniform Design Optimization and Therapeutic Evaluation in Gliomas by Huiqing QueHuiqing Que SciProfiles Scilit Preprints.org Google Scholar 1,*, Wei LiWei Li SciProfiles Scilit Preprints.org Google Scholar 1, Ziting LiZiting Li SciProfiles Scilit...
