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Rhein ameliorates MASH via EGFR/AKT/PPARα-mediated coordinated regulation of metabolism and inflammation

Read more about Rhein ameliorates MASH via EGFR/AKT/PPARα-mediated coordinated regulation of metabolism and inflammation

BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) presents a growing global health challenge with limited therapeutic options. Rhein, an acti Abstract Background: Metabolic dysfunction-associated steatohepatitis (MASH) presents a growing global health challenge with limited therapeutic options. Rhein, an active anthraquinone derived from the...

Association between radiotherapy timing and intracranial outcomes in EGFR-mutant NSCLC with brain metastases treated with EGFR-TKIs

Read more about Association between radiotherapy timing and intracranial outcomes in EGFR-mutant NSCLC with brain metastases treated with EGFR-TKIs

ObjectiveThis study evaluated the treatment outcomes and prognostic factors that influence the overall survival (OS) and intracranial progression-free surviv Abstract Objective: This study evaluated the treatment outcomes and prognostic factors that influence the overall survival (OS) and intracranial progression-free survival...

Translational Research Results of Sacituzumab Tirumotecan (sac-TMT) in Combination with Osimertinib as First-Line Treatment for EGFR-Mutant NSCLC Published in Cancer Cell

Read more about Translational Research Results of Sacituzumab Tirumotecan (sac-TMT) in Combination with Osimertinib as First-Line Treatment for EGFR-Mutant NSCLC Published in Cancer Cell

- The study shows that EGFR-TKIs induce...

Translational Research Results of Sacituzumab Tirumotecan (sac-TMT) in Combination with Osimertinib as First-Line Treatment for EGFR-Mutant NSCLC Published in Cancer Cell

Read more about Translational Research Results of Sacituzumab Tirumotecan (sac-TMT) in Combination with Osimertinib as First-Line Treatment for EGFR-Mutant NSCLC Published in Cancer Cell

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Cytoreductive Surgery During TKI Therapy May Extend Survival in EGFR-Mutated Non-Small Cell Lung Cancer

Read more about Cytoreductive Surgery During TKI Therapy May Extend Survival in EGFR-Mutated Non-Small Cell Lung Cancer

Surgical removal of residual tumour during TKI therapy may improve survival in patients with epidermal growth factor receptor-mutated non-small cell lung cancer TOPLINE: Surgical removal of residual tumour masses during TKI therapy was associated with improved survival in patients with...

Amivantamab Shows Preclinical Immune-Mediated Activity in Mesothelioma Through Dual EGFR and MET Targeting

Read more about Amivantamab Shows Preclinical Immune-Mediated Activity in Mesothelioma Through Dual EGFR and MET Targeting

Amivantamab Shows Preclinical Immune-Mediated Activity in Mesothelioma Through Dual EGFR and MET Targeting Diffuse pleural mesothelioma remains one of the most difficult thoracic malignancies to treat. Despite advances in systemic therapy, there are still limited options designed to directly target...

Targeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer

Read more about Targeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer

Abstract Drug-tolerant persister (DTP) cells play a key role in the development of resistance to EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small-cell lung cancer (NSCLC). Through comprehensive analyses, we identify that TROP2 is dynamically upregulated during TKI-induced DTP formation...

A cholesterol-dependent LRRC8A-caveolin-1 axis sustains KRAS/EGFR signaling, ribosome biogenesis and growth in pancreatic ductal adenocarcinoma

Read more about A cholesterol-dependent LRRC8A-caveolin-1 axis sustains KRAS/EGFR signaling, ribosome biogenesis and growth in pancreatic ductal adenocarcinoma

Cellular adaptive volume regulation is essential for maintaining metabolic homeostasis and supporting survival, yet its role in desmoplastic pancreatic ductal adenocarcinoma (PDAC) remains incompletely understood. Through comprehensive bioinformatic and functional studies, we identified LRRC8A, the core subunit of volume-regulated anion...

Albuminuria, but not eGFR, tracks diabetic retinopathy severity and retinal ischemia: population-based discovery, clinical replication, and OCTA evidence

Read more about Albuminuria, but not eGFR, tracks diabetic retinopathy severity and retinal ischemia: population-based discovery, clinical replication, and OCTA evidence

BackgroundWe investigated whether albuminuria is more consistently associated with diabetic retinopathy (DR) severity than estimated glomerular filtration ra Abstract Background: We investigated whether albuminuria is more consistently associated with diabetic retinopathy (DR) severity than estimated glomerular filtration rate (eGFR) and...

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