Abstract Medicinal plants have long been recognized as reservoirs of bioactive compounds, and Haloxylon articulatum, a halophyte adapted to arid environments, has traditional medicinal relevance. In this study, we systematically investigated the chemical composition, antioxidant activity, and anticancer potential of...

Abstract Liver Cancer is the sixth leading cause of morbidity and mortality worldwide. Effective treatment for HCC is challenging and heavily depends on early diagnosis. There is urgent need to identify a potent therapeutic target for HCC. Among various signaling...

Radiomics-Based Gradient Boosting Model Predicts EGFR Expression and Therapy Response in High-Grade Glioma Using Contrast-Enhanced MRI A recent study published in the *Journal of Translational Medicine* has introduced a radiomics-based gradient boosting model that utilizes contrast-enhanced MRI to predict epidermal...

AbstractColorectal cancer (CRC) is a common malignancy with high incidence and mortality, and tumor angiogenesis plays a crucial role in its progression and metastasis. Although anti-angiogenic therapies are promising, their effectiveness is limited by side effects, drug resistance, and relapse,...

Raffaele Colombo: Subgroup Analysis of Prior EGFR and PD-1 Therapy Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks, shared a post on X:. “Subgroup analyses (caveat, small # of patients):. No correlation between responses and EGFR expression in this...

Elevated Epidermal Growth Factor Receptor (EGFR) expression is observed in most cervical cancers, and it is frequently associated with poor clinical outcomes. The limited efficacy of existing EGFR-targeted therapies in cervical cancer highlights the need for a deeper understanding of...