Abstract Forming organs requires the appropriate distribution of spatiotemporal signals leading to tissue patterning and morphogenesis. Advances in genetic tools contributed to our understanding of cell signaling and their associated genes. Yet, due to technical challenges, the contribution of dynamic...
Abstract Liver cancer (LC) is the fourth most prevalent cause of cancer-related death worldwide. However, existing treatment options have limitations, as they do not consistently provide benefits to all patients. With an emphasis on pyrimidine derivatives, this study uses virtual...
AbstractBackground Uromodulin has been speculated as a protective factor for acute kidney injury (AKI) and chronic kidney disease (CKD), possibly based on the uromodulin-mediated cross-talk between thick ascending limbs and proximal tubules. Here, we explored the roles of uromodulin in...
AbstractBackground Tyrosine kinase inhibitors (TKIs) are widely used to treat non–small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. However, long-term use frequently leads to drug resistance. These resistant cells often exhibit distinct phenotypes from their parental...
AbstractBackground In metastatic colorectal cancer (mCRC), resistance to anti-EGFR monoclonal antibodies persists even in RAS/BRAF wild-type tumors. EGFR’s role in tumor angiogenesis may contribute to this resistance and deserves further exploration. Objective To assess EGFR protein expression and angiogenesis using...
Abstract Advances in assisted reproductive technology (ART) have expanded treatment options for many infertile families. However, outcomes in women of advanced maternal age remain suboptimal, primarily due to fewer retrievable oocytes and diminished embryonic developmental competence. In this study, we...
Abstract Oral squamous cell carcinoma (OSCC) is the most prevalent form of head and neck squamous cell carcinoma (HNSCC), characterized by high incidence rates, frequent recurrence and metastasis, and low survival rates. KLHL4, a member of the Kelch-like family proteins,...
