Furmonertinib plus pemetrexed in the treatment of EGFR exon 19 deletion lung adenocarcinoma: two case reports

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Epidermal growth factor receptor (EGFR) exon 19 deletion (Ex19del) is one of the most prevalent sensitizing mutations in non-small cell lung cancer (NSCLC), Introduction Non-small-cell lung cancer (NSCLC) is a common malignancy worldwide, with adenocarcinoma as the predominant subtype (1,...

Radiomics-based gradient boosting model on contrast-enhanced MRI for non-invasive prediction of epidermal growth factor receptor expression and therapeutic response to EGFR-targeted antibody-drug conjugates in high-grade glioma organoid models

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AbstractBackground Epidermal growth factor (EGF) and its receptor EGF(EGFR) play crucial roles in glioblastoma (GBM) prognosis. However, non-invasive assessment of their expression remains challenging. This study aimed to determine whether radiomics features extracted from contrast-enhanced MRI could predict EGFR expression...

Current and Emerging Treatment Landscape of Common EGFR-Mutated Advanced Non-small Cell Lung Cancer

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Abstract Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has been standard of care as monotherapy for EGFR-mutated advanced non-small cell lung cancer since reporting of the FLAURA phase III clinical trial, which demonstrated superiority over first-generation...

Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study

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AbstractBackground The relationship between kidney function and mortality in centenarians, particularly with respect to hormonal regulation, remains unclear. This study investigated the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians and explored the potential role...

EGFR Signaling Linked to Oral Cancer Pain and Reduced Opioid Effectiveness

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EGFR Signaling Linked to Oral Cancer Pain and Reduced Opioid Effectiveness Researchers have identified a shared biological process involving epidermal growth factor receptor (EGFR) signaling that contributes to both oral cancer pain and reduced effectiveness of opioid medications. The study...

Triple-positive non-small cell lung cancer harboring EGFR mutation, ALK rearrangement, and high PD-L1 expression: a case report and literature review

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BackgroundEpidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are typically considered mutually exclusive i 1 Introduction Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. With the advent of precision oncology, EGFR mutations...

Efficacy of TKIs in non-small cell lung cancer with atypical EGFR p.L747P and p.L747S mutations

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ObjectivesEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are established first-line treatments for advanced non-small cell lung ca Introduction Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for approximately 75-85% of...

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