Acetyl tributyl citrate promotes osteosarcoma progression via EGFR/AKT signaling: an integrated network toxicology and experimental study

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IntroductionAcetyl tributyl citrate (ATBC), a widely used plasticizer, has raised health concerns, yet its role in osteosarcoma (OS) remains unclear. This st 1 Introduction Osteosarcoma (OS) is the most prevalent primary malignant bone tumor in children and adolescents, typically arising...

New Drug Application Submission Completed for Zipalertinib Plus Chemotherapy in First-Line EGFR Exon 20 Insertion Mutation Non-Small Cell Lung Cancer

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This is a paid press release. Contact the press release distributor directly with any inquiries. New Drug Application Submission Completed for Zipalertinib Plus Chemotherapy in First-Line EGFR Exon 20 Insertion Mutation Non-Small Cell Lung Cancer Cullinan Therapeutics, Inc. Thu, November...

Osimertinib, platinum, and etoposide for patients with metastatic EGFR/TP53/RB1-mutant lung cancers at risk for histological transformation

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AbstractAlthough EGFR inhibitors are highly effective for treating EGFR-mutant lung adenocarcinomas (EGFR+ LUADs), resistance inevitably emerges, with histologic transformation to small cell lung cancer (SCLC) representing a particularly aggressive mechanism. Our prospective trial enrolled patients with EGFR+ LUAD at high...

Beyond EGFR Mutations: New Study Reveals Why Some Lung Cancer Cells Survive Osimertinib

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Beyond EGFR Mutations: New Study Reveals Why Some Lung Cancer Cells Survive Osimertinib A patient-derived model of EGFR-mutant non-small cell lung cancer reveals how resistant and sensitive tumor-cell states can coexist despite sharing the same EGFR driver mutation. Published in...

Arctiin attenuates the development of psoriasis-like dermatitis and modulates EGFR-associated ERK signaling

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BackgroundPsoriasis is a chronic immune-mediated inflammatory skin disease characterized by keratinocyte hyperproliferation, immune cell infiltration, and in Abstract Background: Psoriasis is a chronic immune-mediated inflammatory skin disease characterized by keratinocyte hyperproliferation, immune cell infiltration, and increased dermal angiogenesis. Although current...

An integrated computational and experimental framework identifies apigenin as a potential therapeutic agent targeting EGFR/STAT3/MMP9 signaling in glioma

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BackgroundGlioma is the most common primary malignant tumor of the central nervous system and is characterized by aggressive progression, high recurrence rat Abstract Background: Glioma is the most common primary malignant tumor of the central nervous system and is characterized...

Combination Therapy Sustains Survival Benefit in EGFR-Mutated NSCLC

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Combination Therapy Sustains Survival Benefit in EGFR-Mutated NSCLC Ivonescimab plus chemotherapy showed a sustained overall survival (OS) benefit in patients with EGFR-mutated non–small cell lung cancer (NSCLC) who experienced progression during treatment with an EGFR-directed tyrosine kinase inhibitor (TKI), according...

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