Furmonertinib combined with bevacizumab in EGFR-TKI-resistant leptomeningeal metastasis: analysis of the CSF ctDNA molecular response and survival outcomes

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Background Leptomeningeal metastasis (LM) after the development of third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance is indicative of a poor prognosis in EGFR-mutant non-small cell lung cancer (NSCLC), and no standardised treatments are currently available. The aims...

Correction: A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline

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S1-S4 Figure images are omitted from the Supporting Information. It can be viewed below. Supporting informationS1 Fig. Dynamic measurements of the egg chamber dimensions from S7 to S10A. Data was collected at 6 consecutive time-points: 3hr (S7), 7.5hr (S8E), 10.5hr...

Esculetin Attenuates Inflammation and Fibrosis to Prevent AKI-to-CKD Transition in Adenine-Induced Renal Injury by Inhibiting the EGFR/SRC/PI3K/AKT/NF-κB Signaling Axis

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Open AccessArticle Esculetin Attenuates Inflammation and Fibrosis to Prevent AKI-to-CKD Transition in Adenine-Induced Renal Injury by Inhibiting the EGFR/SRC/PI3K/AKT/NF-κB Signaling Axis by Jianglong ChenJianglong Chen SciProfiles Scilit Preprints.org Google Scholar 1, Bin XiaBin Xia SciProfiles Scilit Preprints.org Google Scholar 2,...

EGFR Signaling in Colorectal Cancer: Novel Therapeutic Strategies, Predictive Biomarkers, and Counteracting Treatment Resistance

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Open AccessReview EGFR Signaling in Colorectal Cancer: Novel Therapeutic Strategies, Predictive Biomarkers, and Counteracting Treatment Resistance by Noura AbbasNoura Abbas SciProfiles Scilit Preprints.org Google Scholar , Mohamad MouradMohamad Mourad SciProfiles Scilit Preprints.org Google Scholar , Hiba SmailyHiba Smaily SciProfiles Scilit...

ROCK1 inhibition primes anti-tumor immunity in EGFR-mutant NSCLC by triggering PD-L1 degradation mediated by SMURF2

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Abstract Epidermal growth factor receptor (EGFR) mutations are common in non-small-cell lung cancer (NSCLC) but typically confer poor responses to immunotherapy, likely owing to an inhibitory tumor immune microenvironment. Here, Rho-associated coiled-coil containing protein kinase 1 (ROCK1) was identified as...

Role of cachexia in advanced non-small cell lung cancer patients treated with EGFR-TKIS

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AbstractIntroduction Cachexia is a multifactorial syndrome associated with impaired physiologic reserve and adverse outcomes in advanced NSCLC. Its relationship with early toxicity and survival during EGFR-tyrosine kinase inhibitor (EGFR-TKI) therapy remains insufficiently characterized. We evaluated the impact of baseline cachexia...

Phenotype-specific association of C-reactive protein-to-lymphocyte ratio with incident proteinuric CKD versus isolated eGFR decline: a real-world retrospective cohort study

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BackgroundResidual kidney risk persists in hypertensive patients despite guideline-directed blood pressure (BP) management. Whether systemic inflammation is Abstract Background: Residual kidney risk persists in hypertensive patients despite guideline-directed blood pressure (BP) management. Whether systemic inflammation is preferentially associated with the...

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