National Kidney Foundation and U.S. Pharmacy Organizations Call for Transition to Race-Agnostic eGFR in Medication Decision-Making

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NEW YORK, June 8, 2026 /PRNewswire/ -- A coalition of leading U.S. pharmacy organizations, in collaboration with the National Kidney Foundation (NKF), is urging a nationwide transition to race-free estimated glomerular filtration rate (eGFR), adjusted for body surface area, for...

Prognostic significance of reduced eGFR for kidney outcomes and all-cause mortality in older Japanese individuals with type 2 diabetes and normoalbuminuria: a single-center cohort study

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AbstractBackground Because glomerular filtration rate (GFR) physiologically declines with age, a fixed estimated GFR (eGFR) threshold of < 60 mL/min/1.73 m2 to define chronic kidney disease may overestimate risk in older adults. We examined whether lower eGFR was associated with adverse outcomes...

Afatinib Versus Osimertinib as First-Line Treatment for Advanced EGFR-Mutant Non-Small-Cell Lung Cancer: A 3-Year Follow-Up Overall Survival Analysis

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AbstractBackground To date, there are limited clinical trials comparing the clinical efficacy between second-generation and third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI)s. Objective The objective of this study was to compare the survival outcomes between afatinib and osimertinib...

Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer

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Abstract Neuroendocrine prostate cancer (NEPC) is a lethal, treatment-resistant subtype that arises through lineage transdifferentiation from castration-resistant prostate cancer (CRPC) under selective pressure from androgen deprivation therapy. Although EGFR tyrosine kinase inhibitors (TKIs) represent a rational therapeutic strategy, their clinical...

Machine learning-guided drug repurposing for EGFR inhibition using scaffold-split validation, docking, and molecular dynamics

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Abstract Aberrant epidermal growth factor receptor (EGFR) signaling drives multiple cancers, but the clinical effectiveness of EGFR inhibitors is limited by relapse, toxicity, and mutation-associated resistance. This study applied an integrated computational drug-repurposing workflow combining machine learning-based potency prediction, structure-based...

A combined eGFR-CD4 index and mortality risk among people with HIV: a retrospective cohort study in Taizhou city, Zhejiang province, China

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AbstractBackground Mortality among people with HIV (PWH) increasingly reflects both HIV-related and non-HIV-related causes. Whether a simple index integrating routinely measured kidney and immune function can improve risk stratification remains uncertain. Methods We conducted a retrospective cohort study in Taizhou,...

EGFR Receptors Organize Into Structured Nanoscale Clusters on the Cell Membrane

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EGFR Receptors Organize Into Structured Nanoscale Clusters on the Cell Membrane Researchers have identified that the epidermal growth factor receptor (EGFR) organizes into structured nanoscale clusters rather than existing as solitary molecules within the plasma membrane. These findings indicate that...

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