Piperlongumine inhibits the proliferation and migration of non-small cell lung cancer cells through the EGFR/FAK/STAT3 pathway

Submitted by Anonymous on

AbstractPurpose Lung cancer remains the predominant cause of cancer-related mortality worldwide. Piperlongumine is a natural extract that has antitumor effects. However, the mechanism of Piperlongumine on lung cancer remains to be elucidated. This study aimed to investigate the effects and...

Case Report: Personalized treatment in an advanced lung adenocarcinoma patient with EGFR exon 21 L858R mutations based on the patient-derived tumor organoids

Submitted by Anonymous on

Abstract Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths worldwide. Despite substantial therapeutic advances, the prognosis of lung cancer patients remains dismal. Here, we report a case of advanced lung adenocarcinoma harboring EGFR...

Real-world efficacy of first- and second-generation EGFR TKIs in NSCLC with EGFR co-mutations: a Vietnamese cohort study

Submitted by Anonymous on

AbstractObjective To compare treatment outcomes between first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) in patients with EGFR co-mutated non-small cell lung cancer (NSCLC). Background EGFR mutation is one of the most common genetic alterations in NSCLC; however, the management...

Real-world effectiveness and safety of finerenone in diabetic kidney disease with preserved eGFR: a retrospective study in China

Submitted by Anonymous on

AbstractObjective Given the limited real-world evidence on finerenone in patients with diabetic kidney disease (DKD), particularly with preserved renal function, this study aimed to evaluate the effectiveness and safety of finerenone in DKD patients. Methods We retrospectively analyzed 127 patients...

Molecular modeling and design of new pyridineamide-based antagonists of epidermal growth factor receptor (EGFR) with potentials for lung cancer intervention

Submitted by Anonymous on

Abstract The high mortality and morbidity rates associated with lung cancer pose serious health burden globally. This worrisome circumstance is aggravated by challenges of non-specific targeting, drug resistance, among others. This has necessitated a deliberate search for newer alternatives. In...

Impact of EGFR Mutations on Survival and Clinical Response in Non‐Small Cell Lung Cancer in a Tertiary Care Hospital

Submitted by Anonymous on

Lung cancer continues to be the leading cause of morbidity and mortality associated with malignancies. Identifying prognostic factors is vital for improving survival outcomes. This study assessed the 1 Introduction Lung cancer continues to be the most commonly diagnosed cancer...

Association of EGFR gene polymorphisms rs2072454 and rs2227983 with lung cancer susceptibility in a Western Algerian population: a case-control study

Submitted by Anonymous on

AbstractBackground Data on specific single nucleotide polymorphisms (SNPs), including rs2072454 and rs2227983, remain limited, particularly in North African populations. This study aimed to evaluate the association between these two SNPs and lung cancer risk in a Western Algerian population. Methods...

Relationship between Total Kidney Volume and eGFR in Autosomal Dominant Polycystic Kidney Disease

Submitted by Anonymous on

Clinical Research: Cystic Kidney DiseaseRelationship between Total Kidney Volume and eGFR in Autosomal Dominant Polycystic Kidney Disease Yu, Alan S.L.1; Parker, Chelsie2; Golzarri-Arroyo, Lilian2; Landsittel, Douglas P.2,3; Garg, Rekha4; Lee, Edmund C.4; Chapman, Arlene B.5; Rahbari-Oskoui, Frederic F.6; Mrug, Michal7;...

Subscribe to Newsfeed