EGFR G719X + S768I co-mutations in NSCLC: genomic landscape and differential responses to EGFR-TKIs in a large real-world cohort

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AbstractBackground Comprehensive genomic analysis and optimal treatment for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) G719X + S768I co-mutations remain limited. This study aimed to elucidate the genetic landscape and the clinical effectiveness of EGFR tyrosine kinase...

Disparities in Kidney Disease and the Race-Neutral eGFR - Research and Action in NYC’s Public Hospital System

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PerspectiveEfforts toward Equity Share on Disparities in Kidney Disease and the Race-Neutral eGFR - Research and Action in NYC’s Public Hospital SystemAuthors: Angelica Bocour, M.P.H., Erin Lewis, M.D., Silas Lee, M.S., and Leo G. Eisenstein, M.D. https://orcid.org/0000-0003-4714-6990Author Info & AffiliationsPublished...

Evaluating Oral, Once-Daily ZEGFROVY® (Sunvozertinib) vs. Platinum-Containing Chemo Doublet in First-Line Non-Small Cell Lung Cancer (NSCLC) with EGFR Exon 20 Insertion Mutation (exon20ins)

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Dizal logo (PRNewsfoto/Dizal Pharmaceutical) By Dizal This content is provided by PR Newswire. For questions or concerns, please contact them directly at prncs@cision.com. Treatment with ZEGFROVY® resulted in statistically significant and clinically meaningful improvement in progression free survival (PFS) over...

Evaluating Oral, Once-Daily ZEGFROVY® (Sunvozertinib) vs. Platinum-Containing Chemo Doublet in First-Line Non-Small Cell Lung Cancer (NSCLC) with EGFR Exon 20 Insertion Mutation (exon20ins)

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Treatment with ZEGFROVY® resulted in statistically significant and clinically meaningful improvement in progression free survival (PFS) over platinum-containing chemo doublet WU-KONG 28 is the first and only phase 3 study to demonstrate meaningful benefits with an oral, once daily, chemo-free,...

Microwave-Accelerated C─N Coupling for the Efficient Synthesis of Triazolo[4,3-b]Pyridazine Derivatives With Potent Cytotoxic Activity and EGFR Inhibitory Potential

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ChemistrySelectVolume 11, Issue 12 e06368 RESEARCH ARTICLE Microwave-Accelerated C─N Coupling for the Efficient Synthesis of Triazolo[4,3-b]Pyridazine Derivatives With Potent Cytotoxic Activity and EGFR Inhibitory Potential Krishna Ranjith Kumar, Krishna Ranjith Kumar Department of Chemistry, Vidya Vikas Institute of Engineering &...

Microwave-Accelerated C─N Coupling for the Efficient Synthesis of Triazolo[4,3-b]Pyridazine Derivatives With Potent Cytotoxic Activity and EGFR Inhibitory Potential

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ChemistrySelectVolume 11, Issue 12 e06368 RESEARCH ARTICLE Microwave-Accelerated C─N Coupling for the Efficient Synthesis of Triazolo[4,3-b]Pyridazine Derivatives With Potent Cytotoxic Activity and EGFR Inhibitory Potential Krishna Ranjith Kumar, Krishna Ranjith Kumar Department of Chemistry, Vidya Vikas Institute of Engineering &...

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