Gastric mucosal injury, particularly peptic ulcer-related injury, remains clinically relevant because incomplete or unstable repair may be followed by recurr 1 Introduction Peptic ulcer (PU) is characterized by gastric or duodenal mucosal defects arising from an imbalance between injurious factors...
Risk Stratification and Treatment Selection in EGFR-Mutant NSCLC This segment focuses on identifying clinical factors that influence the use of combination therapy for EGFR-mutant non-small cell lung cancer (NSCLC). This segment focuses on identifying clinical factors that influence the use...
Abstract Adverse pregnancy outcomes represented by recurrent spontaneous abortion remain a global clinical problem, with excessive oxidative stress-induced trophoblast dysfunction as its well-recognized core pathological mechanism. Quercetin is a natural flavonoid with strong antioxidant and cytoprotective effects, but its protective...
ObjectiveTo compare the efficacy and safety of adjuvant almonertinib versus icotinib in patients with resected stage II-IIIA epidermal growth factor receptor Abstract Objective: To compare the efficacy and safety of adjuvant almonertinib versus icotinib in patients with resected stage II-IIIA...
The concurrent occurrence of two histogenetically distinct tumors in a child is exceptionally uncommon and may create substantial diagnostic uncertainty. To 1 Introduction Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignant potential, characterized by proliferation of myofibroblastic...
Abstract EGFR exon 20 insertion mutations represent a distinct subset of non–small cell lung cancer (NSCLC) with limited sensitivity to earlier-generation EGFR tyrosine kinase inhibitors (TKIs). CLN081 (zipalertinib; TAS6417) is a novel covalent EGFR TKI under development with activity against...
Abstract Uncommon EGFR mutations account for approximately 10–15% of all EGFR-mutated non-small cell lung cancer (NSCLC), and the optimal management of unresectable stage III disease harboring isolated EGFR S768I mutations remains poorly defined. We report the case of a 55-year-old...
Bone remodeling requires precise coordination between osteoblast-mediated bone formation and osteoclast-driven resorption. However, directly targetable and therapeutically actionable mediators that can coordinately modulate both processes during regeneration remain relatively limited. Here, we identify immunoglobulin superfamily member 10 (IGSF10) as a...
As third-generation EGFR-tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non-small cell lung adenocarcinoma, especially in patients with brain metastas 1 Introduction Non-small cell lung adenocarcinoma, the most common histological subtype of lung cancer, represents 40%–50% of...
