ctDNA clearance predicts survival in unresectable EGFR-mutant NSCLC: a meta-analysis
BackgroundCirculating tumor DNA (ctDNA) is a non-invasive biomarker for monitoring non-small cell lung cancer (NSCLC). In EGFR-mutant NSCLC, ctDNA clearance 1 Introduction Among the main causes of cancer-related death, on-small cell lung cancer (NSCLC)is still in the forefront of the...
Author Correction: The genomic landscape of response to EGFR blockade in colorectal cancer
Correction to: Nature https://doi.org/10.1038/nature14969 Published online 30 September 2015 In Extended Data Fig. 8 of this article, a micrograph shown in the left column (panel AZD) was inadvertently duplicated during figure preparation. The intended image was meant to show phospho-ERK...
Treatment Patterns and Clinical Outcomes in Unresectable Stage III EGFR-Mutated Non-Small Cell Lung Cancer in China
AbstractIntroduction Following the LAURA study (NCT03521154), the third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) osimertinib was approved for unresectable stage III EGFR-mutated non-small cell lung cancer (NSCLC) after chemoradiotherapy. To inform clinical decision-making, we report real-world (rw) treatment...
A machine learning-based pharmacokinetics predictor (EGFR-PROPK) for EGFR-targeting PROTACs
PROteolysis TArgeting Chimeras (PROTACs) are bifunctional molecules that offer a novel approach to targeted protein degradation, showing particular promise for previously ‘undruggable’ targets. Despite their therapeutic potential, significant challenges remain in optimizing the pharmacokinetic (PK) properties of PROTACs, particularly in...
Association of EGFR and EGF gene polymorphisms with cervical cancer in a case–control study and cross-cancer meta-analysis
Cervical cancer (CC) is one of the most prevalent cancers worldwide. Single nucleotide polymorphisms (SNPs) of the epidermal growth factor receptor (EGFR) and epidermal growth factor (EGF) genes are associated with cancers in diverse populations; However, the roles of these...
Design, synthesis, and evaluation of novel quinazoline-4-one derivatives as potential EGFR-targeting anticancer agents: integrated computational and biological insights
Abstract In this study, molecular hybridization strategy was applied to design, synthesize a new series of quinazoline-4-one derivatives (E1–E8) as potential EGFR-targeting anticancer agents. The synthetic approach involved nucleophilic substitution reactions yielding high-purity compounds, characterized using FT-IR, 1H-NMR, and 13C-NMR...