Risk factors for misclassification in predicting EGFR mutation status using PET/CT imaging in non-small cell lung cancer patients

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ObjectiveThis study aims to develop 10 machine learning models based on positron emission tomography/computed tomography (PET/CT) radiomic features to predic Introduction Lung cancer remains the leading cause of cancer-related morbidity and mortality worldwide, with non-small cell lung cancer (NSCLC) accounting...

Evaluation of eGFR Equations Highlights Need for Accurate Kidney Function Assessment in Chinese Children

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Evaluation of eGFR Equations Highlights Need for Accurate Kidney Function Assessment in Chinese Children A recent evaluation of estimated glomerular filtration rate (eGFR) equations in Chinese children highlights the importance of accurate kidney function assessment in pediatric nephrology. The study...

Keller/eGFR ratio as a simple and useful tool to make a first differentiation between renal aging and chronic nephropathy in large populations

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AbstractBackground Chronic kidney disease (CKD) prevalence increases with age, but distinguishing physiological renal ageing from pathological CKD remains a major diagnostic challenge. Current CKD definitions based solely on estimated glomerular filtration rate (eGFR) often lead to overdiagnosis in elderly individuals...

N-phenylquinazolin-4-amine-based EGFR TKIs suppress pulmonary fibrosis by modulating the EGFR/ERBB3 axis in epithelial–macrophage interaction

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Although EGFR signaling plays a key role in pulmonary fibrosis (PF), its therapeutic targeting remains limited. This study evaluates N-phenylquinazolin-4-amine-based EGFR tyrosine kinase inhibitors (TKIs) in murine models of bleomycin- and radiation-induced PF. These TKIs attenuated fibrosis by modulating the...

Indenoquinoxaline-Based Spiro-Heterocycles: Synthesis, Structural Characterization, MEDT Study, and Dual Inhibition of Kinase-Related Enzymes EGFR and VEGFR2

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Chemistry & BiodiversityEarly View e01597 RESEARCH ARTICLE Indenoquinoxaline-Based Spiro-Heterocycles: Synthesis, Structural Characterization, MEDT Study, and Dual Inhibition of Kinase-Related Enzymes EGFR and VEGFR2 Abdulmajeed Abdullah Alayyaf, Abdulmajeed Abdullah Alayyaf orcid.org/0009-0000-3377-4115 Department of Chemistry, College of Science, King Saud University, Riyadh,...

The impact of EGFR-TKIs treatment on ground-glass opacity-featured lung adenocarcinama

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AbstractPurpose The objective of this study was to comprehensively assess the radiological and pathological impacts of Epidermal Growth Factor Receptor - Tyrosine Kinase Inhibitors (EGFR - TKIs) on ground - glass opacity (GGO) - featured lung adenocarcinoma. This evaluation aimed...

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