Widespread peritoneal metastasis is a key reason for high mortality in ovarian cancer and understanding its mechanisms will offer new targets for the effective treatment of metastatic ovarian cancer. Our previous research revealed that collagen type I alpha 1 (COL1A1)-induced...
AbstractIntroduction Effective July 2022, kidney transplant centers were required to adjust waiting time for Black candidates using a new race-neutral eGFR (estimated glomerular filtration rate) calculation. Little has been reported about the impact and limitations of this policy change on...
Dr Mark Kris highlights a recent study on osimertinib in NSCLC and outlines the best approaches for treatment beyond progression Staying the Course After EGFR Progression A Practical Guide to Treatment in NSCLC Facebook Twitter/X Email Embed undefined This transcript...
AbstractBackground Pancreatic ductal adenocarcinoma (PDAC) often escapes T cell–mediated immunity through impaired major histocompatibility complex class I (MHC-I) antigen presentation, contributing to its limited responsiveness to T cell–based immunotherapies. Because natural killer (NK) cells are capable of eliminating MHC-I–low tumor...
Non-small cell lung cancer (NSCLC) is recognized as one of the most aggressive cancers, and resistance to cisplatin significantly hinders effective clinical treatment. The role of the E3 ubiquitin ligase RNF180 in cisplatin resistance in NSCLC remains unclear. A549/DDP cells...
Abstract Lung cancer remains the leading cause of cancer death globally, highlighting an urgent need for therapies that can overcome acquired resistance. The epidermal growth factor receptor (EGFR) is a well-validated target in non-small-cell lung cancer (NSCLC)however, the continuous emergence...
Clinical Research: Chronic Kidney DiseaseFinerenone and eGFR Slope across Different Levels of Baseline Albuminuria and eGFR Insights from FINEARTS-HF Mc Causland, Finnian R.1; Heerspink, Hiddo J.L.2; Vaduganathan, Muthiah1; Claggett, Brian L.1; Desai, Akshay S.1; Jhund, Pardeep S.3; McGrath, Martina M.1;...
Abstract Natural alkaloids were computationally investigated as putative allosteric modulators of the epidermal growth factor receptor (EGFR) to explore alternative strategies for overcoming resistance associated with T790M and C797S mutations. Density functional theory (DFT), molecular docking, molecular dynamics (MD), and...
Interpreting Overall Survival and CNS Outcomes in EGFR Mutated Metastatic Non-Small Cell Lung Cancer Experts weigh EGFR lung cancer combo therapies, cautioning against cross-trial comparisons and prioritizing CNS efficacy for brain metastases. In this segment, Dr. Singhi discusses how overall...
