Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction

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Alveolar bone resorption during the socket healing process compromises subsequent restoration outcomes. Recent clinical evidence suggests that dental implant placement can effectively prevent such bone loss, yet the mechanisms remain elusive. In this study, combined multi-dataset screening pinpointed sorting nexin...

Structure-based identification, phosphorylation, cyclization and engineering of a self-binding peptide carboxy-terminal to EGFR kinase domain by integrating dynamics simulation, energetics calculation and fluorescence analysis

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Abstract Epidermal growth factor receptor (EGFR) plays a critical role in the pathogenesis of many human cancers. In addition to the extracellular ligand-binding domain and intracellular kinase domain of EGFR that have been widely investigated over the past decades, the...

Dynamic dual regulation of amphiregulin in liver pathophysiology: balancing regeneration and disease progression via the EGFR axis

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Liver diseases, ranging from acute injury to chronic fibrosis and hepatocellular carcinoma (HCC), represent a major global health challenge with limited ther 1 Introduction The human endocrine system regulates physiological processes through the release of various regulatory factors, which are...

Germ-line exon 21 EGFR V831H mutation in advanced NSCLC resistance to almonertinib: a case report

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BackgroundGerm-line EGFR mutations are rare, and their clinical significance, particularly regarding response to tyrosine kinase inhibitors (TKIs), remains p Abstract Background: Germ-line EGFR mutations are rare, and their clinical significance, particularly regarding response to tyrosine kinase inhibitors (TKIs), remains poorly...

Macrophage-Derived Amphiregulin Enhances Schwann Cell Phagocytosis Through the EGFR/CTSS Signaling Pathway

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Abstract Although Schwann cells are non-professional phagocytes, their phagocytic function significantly contributes to myelin debris clearance, a critical process for Wallerian degeneration. However, whether their phagocytic capacity is modulated by professional phagocytes like macrophages remains unknown. This study demonstrates that...

FDA Approves Rybrevant Faspro (amivantamab and hyaluronidase-lpuj) as the Only EGFR-Targeted Therapy that can be Administered Once a Month

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HORSHAM, P.A. (February 17, 2026) – Johnson & Johnson (NYSE: JNJ) today announced the U.S. Food and Drug Administration (FDA) has approved a new, simplified monthly dosing schedule* for Rybrevant Faspro (amivantamab and hyaluronidase-lpuj). When administered in combination with oral...

Radiotherapy has a role to play in patients with EGFR-mutated non-small-cell lung cancer in first-line treatment

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Dirk De Ruysscher, *Pim J J Damen PerspectivesSpotlightVolume 27, Issue 2p155-158February 2026Download Full Issue Download started OkRadiotherapy has a role to play in patients with EGFR-mutated non-small-cell lung cancer in first-line treatmentDirk De Ruysscher ∙ Pim J J Damen [email...

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