精准强化，突破高危：奥希替尼联合化疗助力 EGFR/TP53 共突变伴脑转移晚期 NSCLC 患者实现快速深度缓解_腾讯新闻
随着表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKI）不断迭代发展，EGFR...
Rational design and insilico evaluation of 2-amino-5-methylthiazole derivatives as potent EGFR inhibitors for colorectal cancer therapy
Article summary AI generated Colorectal cancer (CRC) is a significant global health issue, primarily driven by the epidermal growth factor receptor (EGFR), which plays a crucial role in tumor progression. This study successfully designed and evaluated a series of 2-amino-5-methylthiazole...
Dual-template structure-based design of novel harmine derivatives as EGFR inhibitors for colorectal cancer therapy
Abstract Colorectal cancer (CRC) remains a major global health challenge, underscoring the urgent need for novel and effective therapeutic agents. In this study, a dual-template, structure-based drug design strategy was employed to develop fourteen novel harmine-derived inhibitors targeting the Epidermal...
当 EGFR 遇上脑转移与 TP53 突变：从全程管理的角度思考一例有症状的脑转移肺腺癌治疗策略_腾讯新闻
本文仅供医疗卫生等专业人士参考审批号：HS-P-A505A-2605-01435免...
Association of prognostic nutritional index with the risk of all-cause mortality and cardiovascular events in patients with diabetes-related foot ulcers: a non-linear relationship mediated by eGFR
BackgroundDiabetes-related foot ulcers (DFU), a severe complication of diabetes, is strongly associated with high mortality. Although the prognostic nutritio Abstract Background: Diabetes-related foot ulcers (DFU), a severe complication of diabetes, is strongly associated with high mortality. Although the prognostic nutritional...
The eGFR difference between creatinine-based and cystatin-C-based equations is also important in an Asian population within the J-CKD-DB-Ex
Recent studies have shown that a large negative estimated glomerular filtration rate (eGFR) difference (eGFRdiff), defined as the cystatin C–based eGFR minus the creatinine-based eGFR, is related with kidney events. However, whether this association applies to the Japanese population remains...
阿美替尼「靶化」方案 4 周期实现颅内和颅外 PR --一例合并 TP53 等抑癌基因共突变并伴脑转移的 EGFR 突变晚期 NSCLC 病例的启示_腾讯新闻
本文仅供医疗卫生等专业人士参考审批号：HS-NP-A505A-2606-01505...
Clinical implications of serum total VEGF-A and VEGF-A isoforms in patients with EGFR-mutated advanced non-small cell lung cancer treated with EGFR-TKIs
AbstractBackground Vascular endothelial growth factor (VEGF)-A, which is overexpressed in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), has been implicated in resistance to EGFR-tyrosine kinase inhibitors (TKIs). VEGF-A comprises several isoforms, including VEGF121 and VEGF165. However, the...
National Kidney Foundation and U.S. Pharmacy Organizations Call for Transition to Race-Agnostic eGFR in Medication Decision-Making
NEW YORK, June 8, 2026 /PRNewswire/ -- A coalition of leading U.S. pharmacy organizations, in collaboration with the National Kidney Foundation (NKF), is urging a nationwide transition to race-free estimated glomerular filtration rate (eGFR), adjusted for body surface area, for...
Case Report: Successful conversion surgery following chemo-antiangiogenic therapy in a lung adenocarcinoma patient with active rheumatoid arthritis and rare EGFR mutation after immunotherapy-triggered flare
BackgroundFirst-line treatment strategy for advanced non-small cell lung cancer (NSCLC) patients with concurrent driver mutations, high PD-L1 expression, and Abstract Background: First-line treatment strategy for advanced non-small cell lung cancer (NSCLC) patients with concurrent driver mutations, high PD-L1 expression, and...