PD-L1 expression is associated with inferior outcomes independent of EGFR subtype in advanced non–small cell lung cancer with uncommon EGFR mutations treated with first-line second-generation EGFR-tyrosine kinase inhibitors

Submitted by Anonymous on

First-line second-generation EGFR-TKI monotherapy showed no statistically significant differences in efficacy across uncommon EGFR mutation subtypes in advanced NSCLC. In contrast, PD-L1 expression-p CancerVolume 132, Issue 10 e70460 ORIGINAL ARTICLE PD-L1 expression is associated with inferior outcomes independent of EGFR...

Piperlongumine inhibits the proliferation and migration of non-small cell lung cancer cells through the EGFR/FAK/STAT3 pathway

Submitted by Anonymous on

AbstractPurpose Lung cancer remains the predominant cause of cancer-related mortality worldwide. Piperlongumine is a natural extract that has antitumor effects. However, the mechanism of Piperlongumine on lung cancer remains to be elucidated. This study aimed to investigate the effects and...

Case Report: Personalized treatment in an advanced lung adenocarcinoma patient with EGFR exon 21 L858R mutations based on the patient-derived tumor organoids

Submitted by Anonymous on

Abstract Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths worldwide. Despite substantial therapeutic advances, the prognosis of lung cancer patients remains dismal. Here, we report a case of advanced lung adenocarcinoma harboring EGFR...

Real-world efficacy of first- and second-generation EGFR TKIs in NSCLC with EGFR co-mutations: a Vietnamese cohort study

Submitted by Anonymous on

AbstractObjective To compare treatment outcomes between first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) in patients with EGFR co-mutated non-small cell lung cancer (NSCLC). Background EGFR mutation is one of the most common genetic alterations in NSCLC; however, the management...

Serum pentosidine levels are associated with reduced eGFR, including in individuals with preserved renal function: a cross-sectional analysis from the Fukuoka Epidemiological Study of Atherosclerosis

Submitted by Anonymous on

AbstractBackground Advanced glycation end products, particularly pentosidine, are implicated in age-related diseases and are influenced by renal function and glycemic status. Although elevated pentosidine levels are well documented in individuals with chronic kidney disease (CKD) stage G3b or higher, their...

Real-world effectiveness and safety of finerenone in diabetic kidney disease with preserved eGFR: a retrospective study in China

Submitted by Anonymous on

AbstractObjective Given the limited real-world evidence on finerenone in patients with diabetic kidney disease (DKD), particularly with preserved renal function, this study aimed to evaluate the effectiveness and safety of finerenone in DKD patients. Methods We retrospectively analyzed 127 patients...

Association of EGFR gene polymorphisms rs2072454 and rs2227983 with lung cancer susceptibility in a Western Algerian population: a case-control study

Submitted by Anonymous on

AbstractBackground Data on specific single nucleotide polymorphisms (SNPs), including rs2072454 and rs2227983, remain limited, particularly in North African populations. This study aimed to evaluate the association between these two SNPs and lung cancer risk in a Western Algerian population. Methods...

Subscribe to Newsfeed