EGFR/TP53 共突变 NSCLC 伴多发转移患者，奥希替尼联合化疗方案实现肺部病灶及肝转移灶明显缩小，骨转移灶代谢活性下降_腾讯新闻
随着精准医学的发展，表皮生长因子-酪氨酸激酶抑制剂（EGFR-TKI）已成为...
Sophoricoside from sophora japonica L. is efficacious as monotherapy or in combination with lenvatinib in hepatocellular carcinoma via targeting EGFR
Sophora japonica L. is a commonly used traditional Chinese medicine. Sophoricoside (Sop), the isoflavone glycoside obtained in Sophora japonica L., is demonstrated with various pharmacological activities, such as anticancer, anti-inflammation, and immunosuppression. To data, there is a lack of comprehensive...
Sacituzumab Tirumotecan in EGFR-TKI–Resistant, EGFR-Mutated Advanced NSCLC
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Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLC
Original Article Share on Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLCAuthors: Pasi A. Jänne, M.D., Ph.D., David Planchard, M.D., Ph.D., Kunihiko Kobayashi, M.D., Ph.D., James Chih-Hsin Yang, M.D., Ph.D., Ying Liu, M.D., Natalia Valdiviezo, M.D., Tae Min Kim,...
EGFR Combo Helps but Misses Today’s First-Line Needs
Dr Mark Kris breaks down the lazertinib-amivantamab data, noting that the combo shows benefit but fails to address key first-line questions clinicians face in today’s landscape This transcript has been edited for clarity. Hello. It's Mark Kris, from Memorial Sloan...
Uromodulin alleviates fibrosis in acute kidney injury to chronic kidney disease transition by reducing EGFR
AbstractBackground Uromodulin has been speculated as a protective factor for acute kidney injury (AKI) and chronic kidney disease (CKD), possibly based on the uromodulin-mediated cross-talk between thick ascending limbs and proximal tubules. Here, we explored the roles of uromodulin in...
Combined treatment of TKIs with Cilengitide overcomes afatinib-resistance in EGFR-mutated NSCLC cells
AbstractBackground Tyrosine kinase inhibitors (TKIs) are widely used to treat non–small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. However, long-term use frequently leads to drug resistance. These resistant cells often exhibit distinct phenotypes from their parental...