AbstractBackground The renoprotective effects of urate-lowering therapy, especially with selective urate reabsorption inhibitors (SURIs), remain to be established in patients with chronic kidney disease (CKD). This study compared changes in the estimated glomerular filtration rate (eGFR) slope associated with the...
Correction: J Exp Clin Cancer Res 37, 41 (2018) https://doi.org/10.1186/s13046-018-0718-2 Following publication of the original article [1], the authors found errors in Fig. 5c. Figure 5C1 HT29 Cont and Figure 5 C3 SW620 Cont should show the image of HT29...
BDTX bets on silevertinib's broad EGFR mutation reach and CNS activity, but with no approved products, upcoming 2026 data and partnerships are pivotal Key Takeaways BDTX centers its strategy on silevertinib, its only clinical asset in EGFR-mutant NSCLC.Silevertinib shows 60%...
Abstract Non-small cell lung cancer (NSCLC) is the most prevalent subtype of lung cancer, with persistently low overall cure and survival rates, largely attributed to tumor immune escape. This study aims to explore the role of RBM15 in the immune...
Liquid biopsy, particularly cerebrospinal fluid analysis, plays a key role in managing brain metastasis in EGFR-mutant NSCLC. This review highlights its superior ability to detect CNS-specific resist 1 Background Advancements in precision medicine have led to earlier diagnoses of lung...
AbstractBackground and Objective The cytochrome P450 (CYP) system plays a central role in drug metabolism and pharmacokinetic variability, influencing drug–drug interaction risk. The newly synthesized 4-propoxy-2-arylquinoline derivatives (MW1–3) are dual inhibitors of epidermal growth factor receptor (EGFR) and focal adhesion...
Resistance to anti-EGFR therapy remains a major challenge in head and neck squamous cell carcinoma (HNSCC), as adaptive mechanisms driven by drug-tolerant persister cells (DTPs) ultimately compromise treatment efficacy. Here, we identify Interleukin-1 (IL-1)-mediated inflammation as a critical driver of...
Open AccessArticle LL-37 Inhibits EV71 Infection by Upregulating STAC via the EGFR-ERK Signaling Pathway by Jiaqi ZhangJiaqi Zhang SciProfiles Scilit Preprints.org Google Scholar 1,2,†, Hanlin ZhangHanlin Zhang SciProfiles Scilit Preprints.org Google Scholar 3,†, Yi ChenYi Chen SciProfiles Scilit Preprints.org Google...
AbstractPurpose of Review This review examines the mechanisms of acquired resistance to third-generation EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). While genetic bypass mutations are well-understood, the focus here is on lineage plasticity-a non-genetic process where...
