Case Report: Personalized treatment in an advanced lung adenocarcinoma patient with EGFR exon 21 L858R mutations based on the patient-derived tumor organoids

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Abstract Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths worldwide. Despite substantial therapeutic advances, the prognosis of lung cancer patients remains dismal. Here, we report a case of advanced lung adenocarcinoma harboring EGFR...

Real-world efficacy of first- and second-generation EGFR TKIs in NSCLC with EGFR co-mutations: a Vietnamese cohort study

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AbstractObjective To compare treatment outcomes between first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) in patients with EGFR co-mutated non-small cell lung cancer (NSCLC). Background EGFR mutation is one of the most common genetic alterations in NSCLC; however, the management...

Serum pentosidine levels are associated with reduced eGFR, including in individuals with preserved renal function: a cross-sectional analysis from the Fukuoka Epidemiological Study of Atherosclerosis

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AbstractBackground Advanced glycation end products, particularly pentosidine, are implicated in age-related diseases and are influenced by renal function and glycemic status. Although elevated pentosidine levels are well documented in individuals with chronic kidney disease (CKD) stage G3b or higher, their...

Molecular modeling and design of new pyridineamide-based antagonists of epidermal growth factor receptor (EGFR) with potentials for lung cancer intervention

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Abstract The high mortality and morbidity rates associated with lung cancer pose serious health burden globally. This worrisome circumstance is aggravated by challenges of non-specific targeting, drug resistance, among others. This has necessitated a deliberate search for newer alternatives. In...

Impact of EGFR Mutations on Survival and Clinical Response in Non‐Small Cell Lung Cancer in a Tertiary Care Hospital

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Lung cancer continues to be the leading cause of morbidity and mortality associated with malignancies. Identifying prognostic factors is vital for improving survival outcomes. This study assessed the 1 Introduction Lung cancer continues to be the most commonly diagnosed cancer...

Relationship between Total Kidney Volume and eGFR in Autosomal Dominant Polycystic Kidney Disease

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Clinical Research: Cystic Kidney DiseaseRelationship between Total Kidney Volume and eGFR in Autosomal Dominant Polycystic Kidney Disease Yu, Alan S.L.1; Parker, Chelsie2; Golzarri-Arroyo, Lilian2; Landsittel, Douglas P.2,3; Garg, Rekha4; Lee, Edmund C.4; Chapman, Arlene B.5; Rahbari-Oskoui, Frederic F.6; Mrug, Michal7;...

TGM2-TUFM promotes acquired resistance to EGFR-TKIs in EGFR-mutated NSCLC through p62-mediated lipophagy

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AbstractBackground Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) remains the leading cause of treatment failure in advanced non-small cell lung cancer (NSCLC) patients harboring sensitizing EGFR mutations. This study aims to investigate the underlying resistance mechanisms in...

CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression

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AbstractBackground Calcium/calmodulin-dependent serine protein kinase (CASK), a member of the membrane-associated guanylate kinase (MAGUK) family, functions as a multifunctional scaffold protein by engaging diverse binding partners. Although CASK has been implicated in tumorigenesis, its molecular role in the pathogenesis of...

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