AbstractMethods Clinical and genomic data of patients with EGFR-mutant NSCLC were collected from publicly available cBioPortal cohorts. Cohort composition, stage availability, recurrent co-mutations, and study-origin heterogeneity were evaluated. Patients harboring EGFR Del19 or L858R mutations and available survival information were...

This trial compared the efficacy and safety of osimertinib + chemotherapy vs osimertinib alone in patients with epidermal growth factor receptor (EGFR)–mutated advanced non–small cell lung cancer (NSCLC) harboring TP53 mutations. https://jamanetwork.com/journals/ 8/10/2026 12:00:00 AM

This randomized, phase 3 study evaluates the efficacy and safety of first-line osimertinib plus chemotherapy vs osimertinib monotherapy in EGFR-mutated advanced NSCLC harboring concurrent TP53 mutations. https://jamanetwork.com/journals/ 8/10/2026 12:00:00 AM

In recent years, the therapeutic landscape of epidermal growth factor receptor (EGFR)–mutated non–small cell lung cancer (NSCLC) has evolved rapidly, and combination strategies in the first-line metastatic setting are now a standard of care. The FLAURA2 trial showed an improvement...

Correction on: Guo H, Liu L and Baak JPA (2026) Body mass index and fasting insulin predict survival and EGFR-TKI benefit in Stage IV lung adenocarcinoma. Fr A Correction on Body mass index and fasting insulin predict survival and EGFR–TKI...

Lung cancer remains the leading cause of cancer-related mortality worldwide, with nonsmall cell lung cancer (NSCLC) accounting for approximately 85% of all c Editorial on the Research Topic EGFR-targeted therapy in lung cancer: unraveling molecular regulation, overcoming resistance, and advancing...

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EVIDENCE...

Government dialysis programme records 37.6 million sessions for 2.95 million beneficiaries, but experts say totals fail to reveal uninterrupted care or outcomes A parliamentary panel has called for automatic reporting of an additional kidney function measure alongside every creatinine test,...

Gastric mucosal injury, particularly peptic ulcer-related injury, remains clinically relevant because incomplete or unstable repair may be followed by recurr 1 Introduction Peptic ulcer (PU) is characterized by gastric or duodenal mucosal defects arising from an imbalance between injurious factors...

Risk Stratification and Treatment Selection in EGFR-Mutant NSCLC This segment focuses on identifying clinical factors that influence the use of combination therapy for EGFR-mutant non-small cell lung cancer (NSCLC). This segment focuses on identifying clinical factors that influence the use...