Correction: A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline

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S1-S4 Figure images are omitted from the Supporting Information. It can be viewed below. Supporting informationS1 Fig. Dynamic measurements of the egg chamber dimensions from S7 to S10A. Data was collected at 6 consecutive time-points: 3hr (S7), 7.5hr (S8E), 10.5hr...

Esculetin Attenuates Inflammation and Fibrosis to Prevent AKI-to-CKD Transition in Adenine-Induced Renal Injury by Inhibiting the EGFR/SRC/PI3K/AKT/NF-κB Signaling Axis

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Open AccessArticle Esculetin Attenuates Inflammation and Fibrosis to Prevent AKI-to-CKD Transition in Adenine-Induced Renal Injury by Inhibiting the EGFR/SRC/PI3K/AKT/NF-κB Signaling Axis by Jianglong ChenJianglong Chen SciProfiles Scilit Preprints.org Google Scholar 1, Bin XiaBin Xia SciProfiles Scilit Preprints.org Google Scholar 2,...

TGF-α/EGFR-mediated lymphatic metastasis reveals a repositionable therapeutic target in breast cancer

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The epidermal growth factor receptor (EGFR) is a well-established oncogenic driver in multiple epithelial cancers, yet its role in breast cancer remains elusive, with EGFR-targeted therapies showing limited clinical efficacy. Here, we demonstrate that EGFR promotes selective lymphatic dissemination in...

ROCK1 inhibition primes anti-tumor immunity in EGFR-mutant NSCLC by triggering PD-L1 degradation mediated by SMURF2

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Abstract Epidermal growth factor receptor (EGFR) mutations are common in non-small-cell lung cancer (NSCLC) but typically confer poor responses to immunotherapy, likely owing to an inhibitory tumor immune microenvironment. Here, Rho-associated coiled-coil containing protein kinase 1 (ROCK1) was identified as...

Role of cachexia in advanced non-small cell lung cancer patients treated with EGFR-TKIS

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AbstractIntroduction Cachexia is a multifactorial syndrome associated with impaired physiologic reserve and adverse outcomes in advanced NSCLC. Its relationship with early toxicity and survival during EGFR-tyrosine kinase inhibitor (EGFR-TKI) therapy remains insufficiently characterized. We evaluated the impact of baseline cachexia...

Phenotype-specific association of C-reactive protein-to-lymphocyte ratio with incident proteinuric CKD versus isolated eGFR decline: a real-world retrospective cohort study

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BackgroundResidual kidney risk persists in hypertensive patients despite guideline-directed blood pressure (BP) management. Whether systemic inflammation is Abstract Background: Residual kidney risk persists in hypertensive patients despite guideline-directed blood pressure (BP) management. Whether systemic inflammation is preferentially associated with the...

Deep learning framework for predicting EGFR mutation status from H&E whole slide images in lung adenocarcinoma

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AbstractBackground Epidermal growth factor receptor (EGFR) mutations are pivotal molecular drivers in lung adenocarcinoma (LUAD) with significant therapeutic implications, yet conventional molecular testing remains costly, time-consuming, and limited by tissue availability. This study aimed to develop and validate a pathology-based...

TBC1D23 drives lymphatic metastasis in pancreatic ductal adenocarcinoma by altering EGFR cell surface dynamics and signaling

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AbstractBackground Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating malignancies worldwide, characterized by late diagnosis, rapid progression, and dismal survival rates. The discovery of reliable biomarkers for early detection and disease monitoring remains an urgent clinical need. Owing to...

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