Although EGFR signaling plays a key role in pulmonary fibrosis (PF), its therapeutic targeting remains limited. This study evaluates N-phenylquinazolin-4-amine-based EGFR tyrosine kinase inhibitors (TKIs) in murine models of bleomycin- and radiation-induced PF. These TKIs attenuated fibrosis by modulating the...
Chemistry & BiodiversityEarly View e01597 RESEARCH ARTICLE Indenoquinoxaline-Based Spiro-Heterocycles: Synthesis, Structural Characterization, MEDT Study, and Dual Inhibition of Kinase-Related Enzymes EGFR and VEGFR2 Abdulmajeed Abdullah Alayyaf, Abdulmajeed Abdullah Alayyaf orcid.org/0009-0000-3377-4115 Department of Chemistry, College of Science, King Saud University, Riyadh,...
Cardiac hypertrophy is an independent risk factor for heart failure (HF) which often leads to cardiovascular disease-related death worldwide. Here we show that the upregulated expressions of Sorting Nexin 16 (SNX16) are evident in the hypertrophic hearts. Cardiac-specific deletion of...
AbstractPurpose The objective of this study was to comprehensively assess the radiological and pathological impacts of Epidermal Growth Factor Receptor - Tyrosine Kinase Inhibitors (EGFR - TKIs) on ground - glass opacity (GGO) - featured lung adenocarcinoma. This evaluation aimed...
Abstract The co-occurrence of epidermal growth-factor receptor (EGFR) mutation and de novo or acquired MET exon 14 skipping (METex14) mutation in non-small-cell lung cancer (NSCLC) is extraordinarily rare. No more than five cases across multiple studies have been well documented....
Objectives Epidermal growth factor receptor (EGFR)–specific tyrosine kinase inhibitors show less efficacy against the EGFR L858R mutation than EGFR 19del, but no current head-to-head clinical trials 1 Introduction Lung cancer is the leading cause of cancer-related death worldwide [1, 2]....
