Mesenchymal stem cell-induced metabolic reprogramming of EGFR-wild-type tumor cells drives therapeutic resistance in EGFR-mutant non-small cell lung cancer

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AbstractBackground To explore mesenchymal stem cell (MSC)-driven metabolic reprogramming of EGFR-wild-type (EGFR-wt) tumor cells contributing to tyrosine kinase inhibitor (TKI) resistance in EGFR-mutant (EGFR-mt) non-small cell lung cancer. Methods Isolate MSCs from paired tumor and non-tumor lungs of EGFR-mt and...

Integrated in silico pharmacology of Pleurotus ostreatus-derived bioactive compounds targeting EGFR using network pharmacology and molecular

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Abstract Cancer remains a major global health challenge, demanding the development of novel and mechanism-based therapeutic strategies. In the present study, an integrated computational approach involving network pharmacology, molecular docking, ADMET profiling, and molecular dynamics simulations was employed to investigate...

Cost-effectiveness analysis of first-line gefitinib plus anlotinib treatment for patients with stage IIIB–IV EGFR-mutated NSCLC in China

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BackgroundThe FL-ALTER study introduces a novel first-line therapeutic approach for patients with EGFR mutation-positive advanced non-small cell lung cancer Abstract Background: The FL-ALTER study introduces a novel first-line therapeutic approach for patients with EGFR mutation-positive advanced non-small cell lung cancer...

Retinoic acid disrupts cumulus granulosa cells function via EGFR downregulation: induction of PCOS and infertility in adult female mice

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Abstract Polycystic ovarian syndrome (PCOS) is a prevalent metabolic and neuroendocrine disease affecting females of childbearing age. Irregular ovulation, elevated androgen levels, and the presence of multiple ovarian cysts characterize it. This study aimed to investigate the prolonged impact of...

Oncogenic EGFR rewires STING-TBK1 signalosomes to license DNA damage tolerance in NSCLC

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Abstract EGFR hotspot mutations (mEGFR), including primary L858R, exon 19 deletion, and secondary T790M, are pivotal oncogenic drivers in human non-small cell lung cancer (NSCLC). At the same time, NSCLC resistance to third-generation tyrosine kinase inhibitors (TKIs) is a major...

NRP1 Promotes Chronic Lymphocytic Leukemia Progression by Regulating Lipid Synthesis via the EGFR/Akt/SREBP-1 Pathway

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Abstract Dysregulated lipid metabolism in chronic lymphocytic leukemia (CLL) correlates strongly with poor prognosis. Neuropilin-1 (NRP1) is upregulated in CLL and implicated in oncogenic signaling, but its role in lipid reprogramming remains unexplored. To investigate whether NRP1 drives CLL progression...

An extremely rare case of congenital pulmonary airway malformation (CPAM) and atypical adenomatous hyperplasia (AAH) with EGFR mutation in a five-year-old girl

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AbstractBackground Congenital pulmonary airway malformation (CPAM) is the most common congenital lung disorder. Atypical adenomatous hyperplasia (AAH) is a recognized precursor of lung adenocarcinoma. The co-occurrence of CPAM and AAH is exceedingly rare in pediatric patients. Case presentation We present...

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