Health-Related Quality of Life in Patients Previously Treated With an EGFR-TKI From HARMONi: A Phase 3 Trial of Ivonescimab vs Placebo Plus Chemotherapy

Submitted by Anonymous on

Health-Related Quality of Life in Patients Previously Treated With an EGFR-TKI From HARMONi: A Phase 3 Trial of Ivonescimab vs Placebo Plus Chemotherapy Published on 03/27/2026 at 12:28 pm EDT Publicnow Share SUMMIT THERAPEUTICS INC. -4.17% Health-Related Quality of Life...

Natural compounds for non-small cell lung cancer treatment: focus on the EGFR signaling pathway

Submitted by Anonymous on

The EGFR signaling pathway is a critical driver in the occurrence and development of non-small cell lung cancer (NSCLC). However, the inevitable development 1 Introduction Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer...

Small-molecule CBLB inhibitor abolishes EGFR ubiquitination, reduces receptor endocytosis, and diminishes cell motility signaling

Submitted by Anonymous on

Research ArticleCell Biology Share on Small-molecule CBLB inhibitor abolishes EGFR ubiquitination, reduces receptor endocytosis, and diminishes cell motility signalingItziar Pinilla-Macua https://orcid.org/0000-0002-5787-3764, Ratul Mukerji https://orcid.org/0000-0002-6835-3182, Frederick Cohen, and Alexander Sorkin https://orcid.org/0000-0002-4446-1920 sorkin@pitt.eduAuthors Info & AffiliationsEdited by Joseph Schlessinger, Yale University School...

CIRCLE-F/V: a dual-mode CRISPR-Cas13a cascade biosensor for ultrasensitive and visual detection of low-abundance EGFR mutations

Submitted by Anonymous on

Abstract Precise identification of low-frequency EGFR L858R mutations is crucial for targeted therapy and prognosis in non-small cell lung cancer (NSCLC). Here, we present CIRCLE-F/V (CRISPR-based Integrated Restriction-assisted Cyclic Loop-mediated Enhancement Fluorescence/Visual platform), a dual-mode CRISPR-Cas13a cascade biosensor enabling ultrasensitive...

Discrepancy between cystatin C-based and creatinine-based eGFR predicts all-cause mortality in a community-based population: the Takahata study

Submitted by Anonymous on

AbstractBackground Discrepancies between the cystatin C-based estimated glomerular filtration rate (eGFRcys) and the creatinine-based estimated glomerular filtration rate (eGFRcr) have been linked to adverse outcomes in Western populations. However, their prognostic significance in community-dwelling Japanese individuals remains unclear. Therefore, we...

Disparities in Kidney Disease and the Race-Neutral eGFR - Research and Action in NYC’s Public Hospital System

Submitted by Anonymous on

The race-adjusted estimated glomerular filtration rate reduced Black patients’ access to kidney transplants. NYC Health+Hospitals is studying the effect of a race-neutral algorithm PerspectiveEfforts toward Equity Share on Disparities in Kidney Disease and the Race-Neutral eGFR - Research and Action...

The Possible Relationship Between Adverse Drug Reactions and Potential Drug–Drug Interactions in Patients with NSCLC Treated with EGFR Inhibitors

Submitted by Anonymous on

Open AccessArticle The Possible Relationship Between Adverse Drug Reactions and Potential Drug–Drug Interactions in Patients with NSCLC Treated with EGFR Inhibitors by Ivanka MutafovaIvanka Mutafova SciProfiles Scilit Preprints.org Google Scholar 1, Evgeni GrigorovEvgeni Grigorov SciProfiles Scilit Preprints.org Google Scholar 2,...

Subscribe to Newsfeed