DNA base lesion-containing G-quadruplex mediates transcriptome reprogramming in EGFR-TKI resistance of non-small cell lung cancer

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AbstractBackground Cancer cells, such as non-small cell lung cancer (NSCLC) cells, exhibit remarkable phenotypic plasticity and undergo epigenetic reprogramming, characteristics that enable them to evade targeted therapies. However, how NSCLC cells use epigenetic regulatory mechanisms (including endogenous DNA base damage)...

EGFR ligand Angiogenin predicts response to ALK5 inhibition in pancreatic cancer via a TNF-α paracrine axis in tumor-associated macrophages

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Transforming growth factor-β (TGFβ) receptor ALK5 inhibition has shown promise in pancreatic ductal adenocarcinoma (PDAC), but predictive biomarkers remain undefined. We identify angiogenin (ANG) as a negative prognostic yet positive predictive biomarker for ALK5 inhibition combined with chemotherapy. In the...

JAK inhibitors alleviate EGFR-inhibitor-induced diarrhea by protecting intestinal stem cells from adaptive-immune-exacerbated injury

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While intestinal stem cells (ISC) are essential for epithelial homeostasis, their dynamic regulation during immune-mediated injury remains undefined. Here we show that suppression of jejunal ISC proliferation contributes to pathology arising from oral EGFR (epidermal growth factor receptor) tyrosine kinase...

eGFR slope improvement with SGLT2 inhibitors is not statistically associated with changes in urinary protein in Japanese CKD patients: a single-center real-world analysis

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AbstractBackground SGLT2 inhibitors reduce urinary protein and slow eGFR decline in clinical trials. However, real-world evidence on within-patient changes in eGFR slope before and after treatment initiation, and their relationship to changes in urinary protein, remains limited. This study was...

The association between the NT-pro-BNP/eGFR ratio and coronary artery disease severity in Non-ST elevation myocardial infarction

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AbstractBackground While eGFR indicates renal function and NT-pro-BNP aids cardiovascular risk assessment, the prognostic value of their ratio (NT-pro-BNP/eGFR) in non-ST elevation myocardial infarction (NSTEMI) appears to be modest. Aims This study aimed to investigate the relationship between the NT-pro-BNP/eGFR...

Declining eGFR and Uremia Are Associated with Remnant Cholesterol Accumulation and Reduced HDL-C in Non-Dialysis Chronic Kidney Disease

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Open AccessArticle Declining eGFR and Uremia Are Associated with Remnant Cholesterol Accumulation and Reduced HDL-C in Non-Dialysis Chronic Kidney Disease by Hanan AlyamiHanan Alyami SciProfiles Scilit Preprints.org Google Scholar 1, Fahd A. AlshuweishiFahd A. Alshuweishi SciProfiles Scilit Preprints.org Google Scholar...

A Genetically Truncated RGD-Containing Peptide rLj-RGD4 Exhibits Potent In Vivo Antitumor Activity via Induction of Multi-Pathway Apoptosis and EGFR-Targeted Signaling Suppression

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Open AccessArticle A Genetically Truncated RGD-Containing Peptide rLj-RGD4 Exhibits Potent In Vivo Antitumor Activity via Induction of Multi-Pathway Apoptosis and EGFR-Targeted Signaling Suppression by Yuyao SongYuyao Song SciProfiles Scilit Preprints.org Google Scholar 1,†, Huijie YanHuijie Yan SciProfiles Scilit Preprints.org Google...

Updates in the Management of EGFR-Mutated Non-small Cell Lung Cancer (NSCLC)

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AbstractPurpose of Review With the approvals of various targeted therapies including tyrosine kinase inhibitors to antibody–drug conjugates, the treatment landscape of patients with EGFR-mutant non-small cell lung cancer has drastically improved. The use of EGFR-targeted therapies has shifted to include...

Correction: Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway

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Correction: J Exp Clin Cancer Res 37, 41 (2018) https://doi.org/10.1186/s13046-018-0718-2 Following publication of the original article [1], the authors found errors in Fig. 5c. Figure 5C1 HT29 Cont and Figure 5 C3 SW620 Cont should show the image of HT29...

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